Flow Cytometry Analyzer Supplies
Biolegend Recombinant Human CD4 (carrier-free); Reactivity: Human; Apps: BA; Size: 25 μg
Recombinant Human CD4 (carrier-free); Reactivity: Human; Apps: BA; Size: 25 μg
Biolegend AZDye 647 Recombinant Human CC
AZDye 647 Recombinant Human CCL5; Reactivity: Human; Apps: FC, Live cell imaging; Size: 10 μg
Revvity Health Sciences Inc Stainless Steel Beads Bulk, 5 mm, 325 g
Stainless Steel Beads Bulk, 5 mm, 325 g
AdipoGen IL-7 hmonomericFc-KIH h
Recombinant protein. Human IL-7 aa 26-177 is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-7 IL-7 is a hematopoietic growth factor and a member of the IL-7/IL-9 family, which is produced by fetal liver cells, stromal cells in the bone marrow BM, thymus and other epithelial cells, including keratinocytes and enterocytes. The receptor of IL-7, IL-7R, is a heterodimeric complex consisting of the alpha-chain CD127 and the common cytokine receptor gamma-chain, shared with the receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21, and expressed in a variety of cells. IL-7 has a critical developmental function at every stage of T cell development, for both alphabeta and gammadelta lineages, and for the development and survival of naive T cells as well as generation and maintenance of CD4 and CD8 memory.
AdipoGen IL-2 hSwitch-2monome-KIH
Recombinant protein. The extracellular domain of human IL-2 aa 21-153 mutant pH-resistant Switch-2 containing mutations T37H, R38L, T41S, F42Y, and K43G is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta.
AdipoGen IL-27 msFc-KIH h rec
Recombinant protein. IL-27A/p28 aa 29-234 mouseFc Knobs and IL-27B/EBI3 aa 19-228 mouseFc Holes form the IL-27 mouseFc-KIH human using the Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Activates STAT3 phosphorylation in mouse and human cells. Source CHO cells. Lyophilized. Contains PBS Interleukin-12 IL-12 family members are heterodimer glycoproteins, composed of two covalently linked subunits, alpha and beta chains. The alpha-subunit consists of IL-23p19, IL-27p28, and IL-12p35, and the beta-subunit includes IL-12p40 and Epstein-Barr virus-induced gene Ebi3. IL-12 members bind to cognate heterodimeric receptor chains expressed on T cells. This family includes IL-12, IL-23, IL-27 and IL-35 and IL-39. IL-12 and IL-23 are predominantly proinflammatory cytokines that contribute key roles in the development of Th1 and Th17 cells, respectively.
AdipoGen IL-2 hmonomericFc-KIH h
Recombinant Protein. Human IL-2 aa 21-153 is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.IL-2 promotes T cell proliferation and particularly naive T cells.
AdipoGen IL-37 hmonomericFc-KIHh
Recombinant Protein. Human IL-37 aa 46-218 Delta5CysS-S and Y85A see reference A. Bujotzek, et al. 2022 is fused at the C-terminus to a Fc human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. IL-37 IL-1F7 IL-1H4 is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells PBMCs and dendritic cells. IL-37 is a soluble and secreted cytokine of 218 residues that shares the beta-trefoil fold common to IL-1 family cytokines. But IL-37 is an atypical member of the IL-1 family of cytokines as it functions to inhibit many of the major pathways of innate and adaptive immunity and inflammation. It binds to the interleukin-18 receptor IL-18R and its co-receptor SIGIRR.
AdipoGen Fc LALA-PG-KIHIrisin mono
Recombinant protein. Fc LALA-PG KnobsIrisin human, aa 32-143 /mouse, aa 29-140 and Fc LALA-PG Holes form the Fc LALA-PG-KIH humanIrisin monomeric rec. using the Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin. Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
AdipoGen IL-2 Superk MonomFc-KIHh
Recombinant Protein. Human IL-2 aa 21-153 mutant H9 containing the mutations L80F / R81D / L85V / I 86V / I92F is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
AdipoGen IL-12 msFc-KIH h rec
Recombinant protein. IL-12A/p35 aa 23-215 mouseFc Knobs and IL-12B/p40 aa 23-335 mouseFc Holes form the IL-12 mouseFc-KIH human using the Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source CHO cells. Lyophilized. Contains PBS Interleukin-12 IL-12 family members are heterodimer glycoproteins, composed of two covalently linked subunits, alpha and beta chains. The alpha-subunit consists of IL-23p19, IL-27p28 and IL-12p35, and the beta-subunit includes IL-12p40 and Epstein-Barr virus-induced gene Ebi3. IL-12 members bind to cognate heterodimeric receptor chains expressed on T cells. This family includes IL-12, IL-23, IL-27, IL-35 and IL-39. IL-12 and IL-23 are predominantly proinflammatory cytokines that contribute key roles in the development of Th1 and Th17 cells, respectively. IL-27 has both pro- and anti-inflammatory properties and is a potent T cell immunomodulator.
AdipoGen IL-2 hSwitch-2monome-KIH
Recombinant protein. The extracellular domain of human IL-2 aa 21-153 mutant pH-resistant Switch-2 containing mutations T37H, R38L, T41S, F42Y, and K43G is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta.
AdipoGen IL-2 hmonomericFc-KIH h
Recombinant Protein. Human IL-2 aa 21-153 is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.IL-2 promotes T cell proliferation and particularly naive T cells.
AdipoGen IL-38 aa20-152hmonom-KIH
Recombinant Protein. Human IL-38 aa 20-152 is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. IL-38 IL-1F10 belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells.